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PROTO-ONCOGENE PROTEINS C-BCL-2
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DeCS
Descriptor
English
:
Proto-Oncogene Proteins c-bcl-2
Descriptor
Spanish
:
Proteínas Proto-Oncogénicas c-bcl-2
Descriptor
Portuguese
:
Proteínas Proto-Oncogênicas c-bcl-2
Synonyms
English
:
bcl-2 Proto-Oncogene Proteins
c-bcl-2 Proteins
Tree Number:
D12.644.360.075.718
D12.776.476.075.718
D12.776.624.664.700.169
Definition
English
:
Membrane proteins
encoded by the BCL-2 GENES and serving as potent inhibitors of
cell death
by
APOPTOSIS
. The
proteins
are found on mitochondrial, microsomal, and
NUCLEAR MEMBRANE
sites within many cell types. Overexpression of bcl-2
proteins
, due to a translocation of the gene, is associated with follicular
lymphoma.
History Note
English
:
97; was PROTO-ONCOGENE PROTEIN BCL-2 (NM) 1989-96
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
33061
Unique Identifier:
D019253
Occurrence in VHL
:
Similar:
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CID-10
SciELO
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